Todds Syndrome Case Study

Alice In Wonderland (also known as Todd's) Syndrome and Lyme

What is Alice in Wonderland Syndrome? 
"Alice in Wonderland Syndrome is named after a novel that was written by Lewis Carroll. The condition was first illustrated in 1955 by John Todd, a psychiatrist. Todd named it, for Alice's Adventures in Wonderland by Lewis Carroll. Perchance, Lewis Carroll suffered from severe migraine and the disorder as well.

Alice in Wonderland Syndrome is a disorienting condition that affects one’s perception. AIWS is a neurological disorder that disturbs signals that are sent from the eyes to the brain, thereby causing a subsequent distortion in perception. 

The patient complains of visual, auditory and tactile hallucinations and altered perceptions. Alice in Wonderland Syndrome can be baffling and terrifying for the patient; for he feels he is going mad in a weird world with warped perceptions and hallucinations".  Thanks to theAlice In Wonderland site for this information - to read click this link.  


Lyme neuroborreliosis presenting as Alice in Wonderland syndrome.                                                                                  Pediatr Neurol.2012 Mar;46(3):185-6. doi: 10.1016/j.pediatrneurol.2012.01.001.   Binalsheikh IM, Griesemer D, Wang S, Alvarez-Altalef R. Department of Pediatric Neurology, Floating Hospital for Children at Tufts Medical Center, Tufts University, Boston, Massachusetts 02111, USA. alsheikh55@yahoo.com

Abstract:We describe a 7-year-old boy with Alice in Wonderland syndrome associated with Lyme disease. He presented with metamorphopsia and auditory hallucinations in the absence of previous tick bites or other signs of Lyme disease. The boy never developed clinical seizures, and electroencephalograms during these spells indicated no epileptic activity. There was no history of migraine. Cranial magnetic resonance imaging produced normal results. Lyme serology tested positive in both serum and cerebrospinal fluid. He was treated with intravenous ceftriaxone for 3 weeks, with complete resolution of signs. This case report is the first, to our knowledge, of neuroborreliosis presenting as Alice in Wonderland syndrome with complete resolution of findings after intravenous antibiotic treatment.                                   PMID: 22353296 [PubMed - indexed for MEDLINE]

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